Risk factors for ectopic pregnancy: a meta-analysis. This content is owned by the AAFP. Do not forget anti-D immunoglobulin in all Rh-negative patients with bleeding! Ankum WM, Ectopic pregnancy occurs when an embryo attaches outside the uterus, most commonly in the fallopian tubes. The patient’s abdomen was slightly distended, and mild tenderness was present over her lower pelvic area. Abdominal tenderness is variable; it is present in 50% to 90% of patients with ectopic pregnancies. Abdomen was tender and appeared distended. Copyright © 2005 by the American Academy of Family Physicians. ... Ectopic pregnancy: forget the "classic presentation" if you want to catch it sooner: a new algorithm to improve detection. All rights Reserved. Systemic methotrexate therapy versus laparoscopic salpingostomy in tubal pregnancy. PID may be due to N. gonorrhoeae, C. trachomatis, vaginal anaerobes, and/or facultative gram-negative rods. Found inside – Page 105TABLE 6.1 Clinical Presentations of Complications in Early Pregnancy Vaginal bleeding Vomiting and hyperemesis Lower ... Cervical motion tenderness has long been thought to be an important sign for the diagnosis of ectopic pregnancies. Durston WE, Amenorrhea. Women who are haemodynamically unstable, or in whom there is significant concern about the degree of pain or bleeding, should be referred directly to A&E, irrespective of the result of the pregnancy test. The overall conception rate is approximately 77 percent regardless of treatment.3 Rates of recurrent ectopic pregnancy are between 5 and 20 percent, but the risk increases to 32 percent in women who have had two consecutive ectopic pregnancies.2,3, Interested in AAFP membership? Some conditions causing pelvic pain also cause vaginal bleeding. Picciolo C, Diagnosis is by measurement of the beta subunit of human chorionic gonadotropin and ultrasonography. The result is usually a miscarriage. Butler SA, An ectopic pregnancy is a pregnancy that does not occur in the uterus. Dose- and age-dependent ectopic pregnancy risks with intrauterine contraception. 9. Definite cervical motion tenderness and peritoneal signs are the most sensitive and specific examination findings for ectopic pregnancy. Ectopic pregnancy (EP) is a “can’t miss diagnosis” and the leading cause of maternal death in the first trimester. Klausen JH. placenta previa. Barnhart KT, The following minimum criteria have been proposed by the US CDC: uterine/adnexal tenderness or cervical motion tenderness [21]. Hum Reprod. Klausen JH. Mol BW, Found inside – Page 259Cervical motion tenderness is a sensitive sign of pelvic inflammatory disease, but not as specific. Cervical motion tenderness also occurs in about half of women with ectopic pregnancy and about a quarter of those with acute ... Breast fullness. Signs of ectopic pregnancy include. Benjamin I, Gosman G, Cervical motion tenderness may also be found. PMC Docherty SM, Rana P, Kazmi I, Singh R, Afzal M, Al-Abbasi FA, Aseeri A, Singh R, Khan R, Anwar F. Arch Gynecol Obstet. 50 mg per square meter of body surface methotrexate IM, Alternate every other day: 1 mg per kg methotrexate IM and 0.1 mg per kg leucovorin*, LFTs, CBC, and renal function at baseline, Beta-hCG at baseline, day 1, day 3, day 5, and day 7 until levels decrease, Repeat regimen if beta-hCG level does not decrease by 15 percent between day 4 and day 7, Repeat regimen (for up to four doses of each medication) if beta-hCG level does not decrease by 15 percent with each measurement, Beta-hCG level weekly, and continue regimen until no longer detected. The first diagnostic step is to confirm the pregnancy with a β-hCG test, which should be followed by a transvaginal ultrasound to determine the location of the pregnancy and the fetal heartbeat. Therefore, it may be difficult to determine by ultrasonography alone whether an empty uterus indicates early pregnancy or ectopic pregnancy.2,7, Ectopic mass and fluid in pouch of Douglas. How To Differentiate Clinically between Abortion & Ectopic Pregnancy. 23. Found inside – Page 342are indicative of ruptured ectopic pregnancy. Pelvic Examination Y Vaginal bleeding may be observed on per speculum examination Y Uterine or cervical motion tenderness on vaginal examination may suggest peritoneal inflammation. Sahota D, . If transvaginal ultrasonography does not detect intrauterine pregnancy, presumptive ectopic pregnancy is virtually certain when the serum beta subunit of human chorionic gonadotropin level is 1,500 mIU per L (1,500 IU per mL) or greater. 1994;84:1010–5. Symptoms may also mimic ectopic pregnancy. • Discuss diagnostic protocols for ectopic pregnancy • Describe treatment options for patients with ectopic pregnancy TEACHING CASE CASE: A 36-year-old G1P0010 woman presents to the office with onset of light vaginal bleeding, which she feels is not her menstrual period, and mild right lower quadrant pain, which she rates as 2/10. Medical history findings or symptoms suggesting ectopic pregnancy all have likelihood ratios (LRs) of less than 1.5, so the clinician should rely on other findings. A concurrent surgical procedure (e.g., bilateral tubal blockage) is necessary. [] In one study, 9% of patients with ectopic pregnancy presented with painless vaginal bleeding. A fifteen year experience with ectopic pregnancy. Lijmer JG, Eaton A, It is a significant clinical finding that can change the differential diagnosis for a patient and is assessable in female patients of various ages. Dart RG, It is frequently associated with pelvic inflammatory disease (PID), which may lead to stenosis of the fallopian tubes. Diagnosis includes polymerase chain reaction testing of cervical specimens for Neisseria gonorrhoeae and chlamydiae, microscopic examination of cervical discharge (usually), and ultrasonography or laparoscopy (occasionally). Hemodynamic instability and cervical motion tenderness may indicate rupture or imminent rupture. Abdominal pain + likely pregnancy (LMP 9 weeks ago/intermittent condom usage) + surgical abdomen = ectopic pregnancy (likely ruptured) Question # 3 Van der Veen F. Butler SA,

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